Developing a Sustained Drug Delivery System

Developing a Sustained Drug Delivery System 1. INTRODUCTION In last few years, Formulations that are able to extend the release of drug have become an integral part of Pharmaceutical research. It is a centre of exploration due to its many benefits over conventional dosage form. Sustained drug delivery system was aimed to release the medication in a prolonged rate. The basic concept of the sustained release dosage form development is to reduce the frequency of dosage administration, to reduce the fluctuations of drug in the plasma by maintain plasma drug level1 thus improves. Various expressions such as sustained-release ,controlled-release, prolonged-action and repeat action have also been used to describe.. Sustained release offers prolonged delivery of drugs and maintenain plasma levels within a therapeutic range, steady-state plasma levels can be maintained without oscillation2,3. The sustained level of the medication was obtained by controlling the plasma blood level and less frequent dosing4 (Lachman et al., 1987). 1.1 Matrix system is classified into 5 types based on Hydrophilic Matrix System and insoluble hydrophobic Inert Matrix system (6-8) 1.1.1 Hydrophobic Matrix tablet In this technique of sustained release from an oral dosage form the drug is mixed with an inert or hydrophobic polymer and then compressed into a tablet. The sustained release is obtained by dissolving drug and was diffused through a network of channels that exist between compacted polymer particles. The materials used as inert or hydrophobic matrices consist of polyvinyl chloride, polyethylene, and ethyl cellulose and ammonia methacrylate copolymers. The rate controlling phase in these formulations is the solvent penetration into the matrix. The possible mechanism of drug release in the hydrophobic matrix tablet was by diffusion. Hydrophobic matrix tablet consist of porous and nonporous matrix systems. 1.1.2 Hydrophilic matrix tablets The drug molecules are combined with the polymer and erode slowly in body fluids. Hydroxy propyl methyl cellulose is commonly used polymer in the hydrophilic matrix tablets.It is a simple method and widely accepted due to its desirable global regulatory acceptance, cost effective, flexibility in drug release profile matching and ease of commercial scale-up. The different grades of Hydroxypropylmethylcellulose were available for the design of sustained drug delivery system. The viscosity range of the Hydroxypropyl methylcellulose assist in the percentage release rate of drug release. The low viscosity range polymer cause increase in the drug release. The hydrophilic matrix system the mechanism of drug release occurs mainly by diffusion and erosion. In the hydrophilic matrix system the use of cellulosic polymer cause gel formation on the surface of polymer and cause tablet erosion with continuous release of drug. The polymers commonly used in the hydrophilic matrixes are classified into three categories. Cellulose derivatives- hydroxyethylcellulose, Methylcellulose, Hydroxy propylmethylcellulose grades like K4M, K100M, 5cPs, 15cPs and Sodium carboxymethylcellulose. Semi synthetic polymers- Modified starches, Alginates and Chitosan. Acrylic acid Polymers -Carbopol 934 1.1.3. Wax matrix tablets The drugs are embedded into lipid matrix by spray congealing in air and Wax-matrix tablet core consisting of semi-synthetic glycerides and blend congealing in an aqueous media. The congealing process use with or without the aid of surfactants, the wax matrix components are prepared from the blend of powdered ingredients. 1.1.4. Gum type matrix tablets In this type of matrix system the excipients produce gel like consistency in presence of water and the dispersion of the active drug of the tablet was maintained by gel barrier. For example xanthan gum and sodium alginate in water soluble polysaccharides used in gum type matrix systems. appropriate method depends on the properties of the drug, polymer and selection of other ingredients. Many statistical experiments are useful tool to develop sustained release formulation with an optimized formulation with an appropriate dissolution rate with a minimum number of trials. For this reason, a computer based optimization technique with a response surface methodology (RSM) utilizing a polynomial equation and artificial neural network (ANN) has been widely used (Ghosh et al., 2008andBozic et al., 1997). 2.0  KINETICS OF DRUG RELEASE Various mathematical models utilized to interpret the mechanism of the drug release from ER dosage form, with the available dissolution data these release kinetics can be calculated using the model that best fit is selected based on the correlation coefficient (r) value in various models, which gives higher ‘r’ value is considered as the best fit of the release data. The following are the various Release kinetics Cumulative percentage drug released Vs time (In-Vitro drug release plots) Cumulative percentage drug released Vs Square root of time (Higuchi’s plots) Log cumulative percentage drug remaining Vs Time (First order plots) Log cumulative percentage drug released Vs log time (Peppas plots) Calculated regression coefficients for zero order, first order, Higuchi and Korsmeyer-Peppas. The best fit model with the highest correlation coefficient. Table No. 3. Analysis of diffusion release mechanisms Release exponent (n) Overall solute diffusion mechanism 0.5 Fickian diffusion 0.5 Non-Fickian diffusion 1.0 Case II transport n > 1.0 Super Case II transport Zero order release is calculated from the following equation Qt = Q0 + K0 t where Q0 = initial amount of drug Qt = cumulative amount of drug release at time â€Å"t† K0 = zero order release constant t = time in hours It describes the systems where the drug release rate is independent of its concentration of the dissolved substance. The first order release equation is calculated from the following equation Log Qt = Log Q0+ Kt /2.303 where Q0 = initial amount of drug Qt = cumulative amount of drug release at time â€Å"t† K = first order release constant t = time in hours Here, the drug release rate depends on its concentration The Hixson Crowell release is calculated from the following equation is Where Q0 = Initial amount of drug Qt = Cumulative amount of drug release at time â€Å"t† KHC = Hixson crowell release constant t = Time in hours. It describes the drug releases by dissolution and with the changes in surface area and diameter of the particles or tablets A linear plot of the cube root of the initial concentration minus the cube root of percent remaining versus time in hours for the dissolution data in accordance with the Hixson-crowell equation. The Higuchi release is calculated from the following equation Q=KHt1/2 where Q = cumulative amount of drug release at time â€Å"t† KH = Higuchi constant t = time in hours The Higuchi equation suggests that the drug release by diffusion. A graph is plotted between the square root of time taken on x-axis and the cumulative percentage of drug release on y-axis and it gives a straight line. Korsmeyer – peppas equation is F = (Mt /M ) = Kmtn Where F = Fraction of drug released at time ‘t’ Mt = Amount of drug released at time ‘t’ M = Total amount of drug in dosage form Km = Kinetic constant n = Diffusion or release exponent t = Time in hours An optimal experimental formulation was compared with the original product, in order to compare the profile of the in vitro release of the drug. 3.0  BIOAVAILABILITY STUDY: Stabilitytesting of Drug products conducted as per ICH conditions the formulations which are stable up to 6M 40 °C/75% RH and 25 °C/60% considered as stable formula taken up for in vivo absorption study. In current scenario in vitro and in vivo performance of the dosage forms is essential part of Product development. The FDA guidelines respecting the IVIVC method evaluation used to set dissolution specifications; which can be applied for surrogate for in vivo bioequivalence for certain pre- or post approval changes, such as Equipment, facility or Manufacturing process changes and minimizes the bioavailability or bioequivalence study after the formulation design optimization The ultimate aim of IVIVC is to select the suitable dissolution method of in vivo absorption of the test compound. In IR tablets the release is more rapid in ER, the excipients also having bio pharmaceutical activity and controls the release within the body. Generally HPMC matrices are biocompatible and do not have enzyme degradation by gastric fluids. For Biovailability study the following Pharmacokinetic parameters to be studied they are Tmax, Cmax and AUC can be evaluated via Plasma or Urine data. Pharmacokinetic assessment the plasma drug concentrations determined by HPLC analysis. Drug extracted from plasma sample by liquid-liquid extraction method, To study the rate and extent of absorption of Cilostazol and Etodolac extended release matrix tablets 100 with that of 100 mg reference(R) conventional marketed formulations and IR tablets The research study was performed in rabbit model to evaluate the pharmacokinetics and then for IVIVC studies. The simple HPLC method used to evaluate to determine the drug content in plasma, the in-vitro studies shows the release pattern is slow first order, For Cilostazol the overall Cmax, Tmax, AUC0-t, Kel and T1/2 were completely different between both test and reference formulation (IR). Therefore the prepared formulation was releasing the drug for a prolonged period of time In case of Etodolac the Cmax, Tmax, AUC0-t, Kel and T1/2 were completely comparable with the reference product; therefore the prepared formulation was releasing the drug for a prolonged period of time and bioequivalent with reference product.

A Painful Childhood Experience Essay example -- essays research papers

Painful Childhood Experiences In a child’s world, there is always a lot of imagination. Children create worlds of their own out of their familiar surroundings, despite what adults tell them. The only way to let them realize the truth is to make them experience it, as Rosaura from â€Å"The Stolen Party† and An-mei from â€Å"Scar† do in their lives. Liliana Heker’s â€Å"The Stolen Party† and Amy Tan’s â€Å"Scar† share a similar theme. Both stories follow the perceptions of young girls. Although Tan’s â€Å"Scar† and Heker’s â€Å"The Stolen Party† share a distinct resemblance, they also differ. Rosaura suffers the pain that others give to her, but An-mei suffers it from her loved ones, such as her grandmother. The main similarity is that both Rosaura and An-mei suffered from the painful circumstances of their lives. Rosaura convinces herself that Luciana is her friend and that she has been invited to Luciana’s birthday party as any other guests. For Rosaura, there is the proof that every afternoon she goes to Luciana’s house and they do their homework together. That is all the evidence Rosaura needs to consider herself a friend to Luciana. She even helps out with some chores during the party thinking she has some sort of â€Å"special† status in the house because of her familiarity with Luciana’s home, as Heker states, â€Å"Rosaura was the only one allowed into the kitchen. Senora Ines, Luciana’s mother also says, â€Å"You yes, but not the others, they’re much too boisterous, they might break something.† Rosaura ha...

Civil Disobedience: Are We Morally Obliged to Obey Unjust Laws? Essay

Are we morally obliged to obey even unjust laws? This question raises the discussion of what we call civil disobedience. Elliot Zashin, author of Civil Disobedience and Democracy, defines civil disobedience as, â€Å"a knowing violation of public norm (considered binding by local authorities but which may ultimately be invalidated by the courts) as a form of protest: it is non-revolutionary, public, and nonviolent (i.e. there is no use of physical violence except self-defensively when participants are physically attacked, and no resistance to arrest if made properly and without undue force).† (Zashin, 118) One point that Carl Cohen, associate professor of philosophy at University of Michigan, thinks is essential to the definition is that the, â€Å"mere knowledge of the unlawfulness does not make it civil disobedience†¦the civil disobedient must do more than knowingly break the law. Absolutely essential is the further element of protest.† (Cohen, 11) In other words, civil disobedience is knowingly breaking a law to protest the law. This may not be as controversial as some topics, but there are many strong points on both sides. A major objection is tied to the idea of social contract theory as well as extreme faith in the proper workings of the judicial and legislative systems. According the this objection, the government of the United States, which calls itself democratic, for instance, is set up to listen to the needs of the people and to make laws accordingly. There is no need to protest or to â€Å"civilly disobey† because the government’s job is to take care of such problems. Socrates, a Greek philosopher, when forced with a suicide execution refused escape because he had profited from the laws of Athens thus far, was given a... ...tic government. BIBLIOGRAPHY  · Cohen, Carl, Civil Disobedience, Tactics and the Law. 1971, Columbia University Press: NY. Pgs: 3, 5, 6, 9, and 11.  · â€Å"Declaration of Independence† ONLINE: http://www.archives.gov/national_archives_experience/declaration_transcript.html. 20 Nov 03  · Singer, Peter, Practical Ethics: Second Edition. 1993, Cambridge University Press: Cambridge, UK. Pgs: 298-306  · Smith, Michael P, et al, Political Obligation and Civil Disobedience Readings. 1972, Thomas Y. Crowell Company: NY. Pgs. 179, 180, and 183.  · Suber, Peter, â€Å"Civil Disobedience.† ONLINE: http://www.earlham.edu/~peters/writing/civ-dis.htm. 19 Nov 03.  · Zashin, Elliot M., Civil Disobedience and Democracy. 1971, The Free Press: NY. Pgs. 118, and 131.

Social Welfare System in Hong Kong

Question 1: Identify one type of the social welfare, discuss its services of Hong Kong and a)explain its values, rationales and objectives; b)ways of service delivery; c)discuss the strengths and weaknesses of the service and d)make suggestions to improve the services in future. CSSA—AN INTRODUCTION The comprehensive Social Security Assistance Scheme (CSSA) is surely one of the most influential social welfare in Hong Kong, in terms of money and beneficiary.In the fiscal year of 2010 alone, 19 billion was spent on CSSA, which increased noticeably by 40% as compared with the expenditure ten years ago. As at the end of 2009, total number of CSSA cases amounted to 289 139, representing an increase of 25. 3% over 1999. CSSA accounted for 8. 6% of government recurrent expenditure, compared with 7. 5% in 2000. During 1999 to 2009, the average growth in total number of cases per annum was 2. 3%. In fact, the growth rate of CSSA cases is expected to accelerate because the growth of eld erly population will peak in 2016-2026.In other words, the problem is not coming yet. But it will within 10 years. In view of the potential alarming situation, there is an urgent need to investigate the effectiveness of the scheme. This essay will give a brief review of the captioned scheme as well as to discuss possible ways to improve the services in the future, making the most effective use of government resources. CSSA—ITS VALUES, RATIONALES AND OBJECTIVES The CSSA Scheme was introduced in 1993, replacing the former Public Assistance Scheme, and evolved over the past 20 years into the current complex system.It is designed to provide a safety net for individuals or families who cannot support themselves financially for various reasons such as old age, disability, illness, unemployment and low earnings. The CSSA Scheme provides financial assistance to bring the income of such individuals or families up to a prescribed level to meet their basic needs. All CSSA recipients are entitled to free medical treatment at public hospitals or clinics. It is administered by the Social Welfare Department (SWD) and is non-contributory but means-tested.APPLICATION REQUIREMENTS To be eligible for assistance, the applicant must satisfy the residence requirements, that is, to have resided in Hong Kong continuously for at least one year before the date of application and be a Hong Kong resident for seven years. Yet, exception can be granted for discretion. They must also pass both the income and assets tests. To pass the income test means the applicant’s total assessable monthly household income is insufficient to meet their total monthly needs as recognized under the Scheme.To pass the asset test means the total value of the capital assets held by the applicant is below the prescribed limit. If the applicant lives with other family members, the application shall be made on a household basis. On top of the basic subsistence support, there is a number of supplement s, like disability, old age, community living, single parent, transport supplement, which is too excessive to mention here. A person can make an application directly to a social security field unit, or by referral to the Social Welfare Department by another government department or a non-governmental organization.Upon receipt of an application, staff of the SWD will conduct investigation and verification of the applicant’s circumstances. It is usually completed in a month and is very convenient. CSSA—ITS STRENGTHS AND WEAKNESSES Generally speaking CSSA has been quite effective in providing a safety nets towards the needy, whether the amount of grants is sufficient or not is subject to argument, one has to acknowledge the fact that there is no major starvation/freezing death caused by poverty in recent years. The general living conditions and nutrition’s of the poor improved, compared many years ago.In the past, social welfare is just a feeding station, or remedy measures after the problems exist, CSSA, with its recent reform of adding more and more subsidies like disabilities, elderly, transport supplement†¦etc, is a rather complicated cash transfer framework, which definitely, effectively created a safety net and contributed a part of improving peoples’ living standard. It seems that CSSA was able to fulfill the very basic philosophy of social security policy and social policy in general terms, which is residual or remedial. CSSA is somewhat a passive scheme as a rescue if the applicant himself, or his family failed to help.It is remedial because it functions only if you fall and will not prevent you from falling. This is of no doubt that CSSA can solve immediate issues, but not the root of it. In fact there are changes that CSSA can make to help better cope with this problem. Moreover, there is room of improvement of the efficiency of the scheme, as it has become more and more complex that something can be done to make it mor e efficient as a safety net. And as progress, it is vital that we look at the possible policy that can be adjusted to better cope with the situation as things do change over time.One of the major characteristics of CSSA is that it is a means tested scheme. In a nutshell, as long as the applicant meets the requirements, the applicants are entitled to get the benefits, as a matter of right. What they do is to assess the quantitative elements of the applicants, such as how many assets they have, how much they earn per month, the severity of his sickness, and treat them as fair as possible, without looking at their background, their ability, the reason they apply for the scheme.As a government servant, I comprehend the difficulty to do so because their job is to do assessment on the financial criteria. But CSSA is not just simple financial assistance, ideally speaking. When the unemployed come for assistance, their problem is not just short of money for assistance, they are unable or no t willing to find jobs which they do not like or do not match their skills or think the wage is too low for him. Recent news reporting a postgraduate graduated from The Chinese University of Hong Kong is an example. CSSA applicants have problems besides financing.I dare say a considerably proportion of staff running the program are not equipped with the skills that can deal with the key issue, thus missed the chance of preliminary investigation of the candidate while looking at the documents and data before the grant. However, CSSA is far from sufficient to provide something constructive, to help the recipients for taking constructive acts to participate in society. Right now we see that, the community is increasingly dependent, which is harmful. The CSSA should abandon the passive strategy of simply looking at needs and handing out cash.This can be done by demanding the recipients to take steps to help themselves as a prerequisite to receive the payments. It has in fact already bee n adopted and have a positive result. With the introduction of the intensified Support for Self-reliance Scheme measures in June 2003, there was a rapid deceleration in the rate of increase in unemployment cases during June to September 2003, the number of cases also started to decline as from October 2003 to October 2008. But the unemployment case started to rise since 2009, and almost reached the level of 1999, which is the year of financial crisis.As a suggestion, the said scheme can add community service work as a component of the criteria of getting subsistence, such as to clean toilets in governmental departments, of some minimum hours per month as a way to encourage them to contribute to the society. Back to the postgraduate in CU as an example, of course he will get something better than looking after elderly as a job! Even if he cannot do so what he has done will be beneficial to the society. Moreover, the scheme is becoming more complicated as more and more supplement and discretionary items have been added.It is no longer a system that is administratively simple or efficient. The lack of training of the said officials and the complexity the system deter the efficiency of the officials to tackle the applicants specific needs, rather in a degree enhanced their reliability on CSSA. Alternative of solving the problems, despite of training workers, is to tidy up the current structure of the administration, such as diving the recipients into categories, with their own eligibility criteria, referrals, conditions of assistance and kinds of help to offer.Bureau working on this will be, despite more systematic, will have a much more clear idea of how to help the applicant and in turn, the applicant received a better idea of their benefit and get better helped. For instance the financial needs of the elderly should be considered with their health care. They may, because worrying insufficient money to pay their health care, save the already little grants receiv ed from CSSA, sacrificing their living quality. There seems little cooperation with the Social Welfare department with relevant charity organizations.The same applies to other groups, like, for single parents family, which they save the CSSA for family services. I have already made the point through the above that CSSA, generally speaking is effective and have done a good job in providing a safety net to Hong Kong, by a one-way handout of cash. But it can, in fact, requiring the recipients to contribute back to the society by adding a component of voluntary services element into the scheme. This, on one hand can screen out people who do not really need CSSA, thus focusing to the resources and attention to those desperately in need.And on the other hand to help those screened out forcing them getting back to the mainstream. And as mentioned about, the efficiency of the CSSA system can be more efficient by adopting a categorical approach, better matching the skills of staff working th erein and the background of recipients. In a nutshell, CSSA do create some sort of dependency because, looking at the amount of CSSA cases and the economy of Hong Kong it is not very much correlated. That suggests that the determining factor for the number of people on welfare is, maybe the welfare system itself.Therefore it is very critical for the government to formulate its social welfare policy so that the policy will not create dependency by itself, better organizing structure of manpower, so the budget can save a few billion and most importantly, better matching of resources and helping those really in need. (1719 words) Reference: 1. Research and Statistics Section, Social Welfare Department, Statistics on Comprehensive Social Security Assistance Scheme, 1999 to 2009 2. Social Welfare Department, A Guide to Comprehensive Social Security Assistance

School Prayer

Amy Hua English 1A TTh 1:45-3:10 Professor Marvin School Prayer Annie Laurie Gaylor argues against school prayer in her article â€Å"The Case against School Prayer† (Elements of Arguments, 679). When religion is included in daily school routines, it divides students into different beliefs. Public schools are meant to be open for all people to get an education, but not to influence them into a new religion. Requiring students to practice prayer in public schools is a violation of Freedom of Religion.Public schools should not practice prayer because there is a diversity of religions in the United States and the Constitution of the First Amendment. Students in public schools get distracted from judgment of religion, but that is why there are places where schools may freely practice religion, such as private schools. Due to the diversity of religions, along with dissimilar practices, schools should continue their public structure leaving religion entirely out. Public schools educ ate the belief of God, which might (for example) be the religion of Catholicism.High schools, Middle schools, and maybe even Elementary schools that practice a certain religion might offend or hurt other religions. â€Å"When religion has invaded our public school system, it has singled out the lone Jewish student, the class Unitarian or agnostic, the children in the minority† (Gaylor 679-680). The United States has a vast variety of religions that include Buddhist, Christian, Catholic, Hinduism, Islam, etc. There are also those Atheists who do not believe in any God. Each belief practices different events that may contrast.For instance, Christians rejoice to the Lord on Christmas day as a result of the birth of Jesus Christ, whereas, Buddhists pay their respects to the dead. â€Å"Congress shall make no law respecting an establishment of religion, or prohibiting the free exercise thereof. (First Amendment, Bill of Rights, U. S. Constitution)† The First Amendment is th e Freedom of Religion, press, and expression. Praying at schools not only excludes the students who do not believe in God, but also disrespects them by not allowing freedom of other religions.Forced into prayer does not verbally influence the student to believe in God, but it still implies that you cannot or should not practice a different religion. Most of the rules in public schools are useful: do not use profanity, attend school, and do your best at anything you set your mind to. No matter what the religion, these rules are useful to everyone and are universal to all countries because each one agrees with them. Teaching students about religion would be equivalent to converting them towards the American Republican Party or Democratic-Republican Party.For schools today, it is dishonest for teachers to promote subject during class period. Instructors cannot force what is not universal because of the different beliefs each religion practices. There will be disagreements among singula r religions because there is not only one type of prayer system. There is a place for religion in schools. Private schools were made to eliminate the government from its system, so they are independent. Although students in public schools should be allowed to have personal prayers, there are also private schools and universities that focus on certain viewpoints on religion.If required, some private schools are given permission to freely practice their own religion. For example, Messiah College and John Brown University concentrate on Bible studies as much as other electives. It is more of an option to attend private schools, like Messiah College, so the student should know what he or she is signing up for. However, public schools are for all students to learn gender education. Therefore, no assumption of religion should be taught as a part of general education.As a child, I was enrolled into private Christian school by my parents. My parents and I were aware of the education I was b eing taught by the teachers and the sharing of general education and Bible studies. In â€Å"The Case against School Prayer†, Gaylor says â€Å"People should be judged by their actions, not by what religion they believe in or how publicly or loudly they pray† (82). Not only do people get distracted from judgment, but also from their studies from far most important subjects.With religion being in the same studies as Math and Science, students are unable to concentrate in studies that will mainly shape their future. Prayer can be harmful in many ways, depending on how much the school interoperates it daily. When I attended a Christian school during Kindergarten through fifth grade, I was required to announce the Pledge of Allegiance. But when my parents decided to take me out of Christian school and enroll me into public school, the Pledge of Allegiance was still mandatory to say.My parents, who converted into Buddhism, were offended that I still had to intentionally wor ship God. Annie Gaylor and, not to mention, Jesus had the same opinion for not allowing public schools to teach religion. â€Å"†¦when thou prayest, enter into thy closet, and when thou hast shut thy door, pray to thy Father which is in secret† (Bible, Matt. 6:5-6). School prayers add conflict to education in many ways. As a result of the vast amount of religions in the United States, there are conflicts caused my disagreements of religion. Japan, where no one prays at school, had the lowest crime rate of any developed nation† (Gaylor, 683). Religion should only be taught in private schools or organizations. The First Amendment was made for Freedom of religion, press, and expression, meaning that everyone has a right to pray, but not for public schools to convert the students into believe a certain religion. I strongly agree on Gaylor’s viewpoints of school prayers because I was felt in the same situation in the past. Public schools should stay open to diffe rent religions.

Making Choices about Exigency, Genre, and Readership Essay - 1

Making Choices about Exigency, Genre, and Readership - Essay Example Thinking about genre will enable the writer to consider the style and manner of writing. Considering about readership will compel the writer to engage with the subject being written and not just to write to comply to the requirements of an assignment. I have to admit that the only person I thought of in my previous writing classes is my teacher on how to satisfy him or her so I can get better grade. Writing for an ideal community of readers compels me to find ways to meet the expectations of those who are already interested in my topic and for them to consider my perspective, accept my explanations, arguments and proposals. Writing for a class is primarily motivated by compliance or as a response to the requirement of a class. This may or may not engage the writer as he or she writes the paper. Writing for â€Å"real† readers on the other hand, engages the writer about the subject being written in order to convince its real readers to adopt his or her point of view or be convince with the persuasion of the

Business Simulation Game (Individual Report) Essay

Business Simulation Game (Individual Report) - Essay Example ment of a foot-wear company operating in Europe-Africa, Latin America, Asia-Pacific and North America and the strategic decisions that the virtual company has made from its Year 10 to Year 15 of operation. The company operates in four different geographical areas; Europe-Africa, Latin America, Asia-Pacific and North America. This means the company operates in different political atmospheres. It thus has to deal with the problems and challenges of political ambiguities and turbulence. In order to create a political environment that is amenable to our business, we have pursued political risk management strategies. We have taken advantage of the growing global awareness and entered into the global market. As globalization leads to more business opportunities for our company, we have to change the roles of the business game and strategize accordingly with the changing dynamics. We appreciate that different organizational players and settings shape our business opportunities through different public policy processes in the locales that host our operations. Before settling on any particular strategy to take control of the political uncertainty, our company further considered the High Involvement Strategy. This involved contemplating the possibility of expending great resources and developing a more elaborate strategy. The strategy would be geared towards effecting the political environment in ways that would yield maximum returns to our efforts. Using this strategy, the company did not abandon the idea of networking with other similar-minded firms. Instead of coalition with like-minded firms to gain scale, the strategy would be for diverse parties to gain scope. All companies, organizations and agencies are potential members of the High Involvement Strategy. The strategy would include networking of regional, local, national, political, economic and social actors. Through frequent communication and contact, the network behaves like an information-gathering device that